GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2274273 | 1 | rs6573006 | chr14:55610432 | FBXO34 | chr14:55738021-55893431:+ | -0.15 | -3.52 | 0.000479 | Protein biomarker |
| THCA | cis | rs2274273 | 1 | rs6573006 | chr14:55610432 | KIAA0831 | chr14:55833110-55878576:- | -0.13 | -3.68 | 0.000262 | Protein biomarker |
| THCA | cis | rs8192917 | 1 | rs6573911 | chr14:25100933 | GZMB | chr14:25100161-25103432:- | 0.16 | 4.01 | 6.96E-5 | Vitiligo |
| THCA | cis | rs935334 | 1 | rs6574278 | chr14:76663838 | ESRRB | chr14:76837690-76968178:+ | 0.32 | 5.2 | 3.01E-7 | Blood pressure |
| THCA | cis | rs6574644 | 1 | rs6574639 | chr14:81771541 | STON2 | chr14:81727000-81893748:- | 0.21 | 4.27 | 2.34E-5 | Obesity-related traits |
| THCA | cis | rs6574644 | 1 | rs6574641 | chr14:81774111 | STON2 | chr14:81727000-81893748:- | 0.21 | 4.2 | 3.16E-5 | Obesity-related traits |
| THCA | cis | rs6574644 | 1 | rs6574642 | chr14:81774316 | STON2 | chr14:81727000-81893748:- | 0.21 | 4.2 | 3.16E-5 | Obesity-related traits |
| THCA | cis | rs6574644 | 1 | rs6574643 | chr14:81774402 | STON2 | chr14:81727000-81893748:- | 0.21 | 4.2 | 3.16E-5 | Obesity-related traits |
| THCA | cis | rs6574644 | 1 | rs6574644 | chr14:81778644 | STON2 | chr14:81727000-81893748:- | 0.21 | 4.2 | 3.16E-5 | Obesity-related traits |
| THCA | cis | rs9948 | 1 | rs6576986 | chr2:97508320 | LOC729234 | chr2:96676299-96688882:+ | -0.24 | -3.35 | 0.000862 | Erectile dysfunction and prostate cancer treatment |
| THCA | cis | rs6120141 | 1 | rs6579083 | chr20:31760708 | C20orf70 | chr20:31755960-31769223:+ | -0.46 | -3.99 | 7.71E-5 | Smooth-surface caries |
| THCA | cis | rs867186 | 1 | rs6579208 | chr20:33598612 | PROCR | chr20:33758727-33765164:+ | -0.34 | -5.65 | 2.75E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs6579208 | chr20:33598612 | TRPC4AP | chr20:33590215-33680618:- | 0.28 | 3.48 | 0.000549 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs6579210 | chr20:33605802 | PROCR | chr20:33758727-33765164:+ | -0.32 | -5.28 | 1.92E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs6579211 | chr20:33605857 | PROCR | chr20:33758727-33765164:+ | -0.36 | -5.7 | 2.14E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |